Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction.
نویسندگان
چکیده
SCN5A gene encoding the cardiac sodium channel. Genomics 1996;34:9– 16. 13. Makielski JC, Ye B, Valdivia CR, Pagel MD, Pu J, Tester DJ, et al. A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels. Circ Res 2003;93:821–8. 14. Hiraoka M. Inherited arrhythmic disorders in Japan. J Cardiovasc Electrophysiol 2003;14:431–4. 15. Vatta M, Dumaine R, Varghese G, Richard TA, Shimizu W, Aihara N, et al. Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet 2002;11:337–45. 16. Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, et al. The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet 2004;41:e66.
منابع مشابه
Evaluation of imprecision for cardiac troponin assays at low-range concentrations.
BACKGROUND The European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction (MI) has recommended that an increased cardiac troponin should be defined as a measurement above the 99th percentile value of the reference group. A total imprecision (CV) at the decision limit of </=10% is recommended. However, peer-reviewed data on assay impreci...
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Cardiac troponins in blood are the most sensitive and specific biochemical markers of myocardial damage and are paramount for classification, risk stratification, and customized therapy in patients with acute coronary syndromes (1, 2). Despite the overt advantages, some important obstacles to troponin analysis and interpretation have remained, such as assay standardization, interference, preana...
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We have for many years advocated for very precise cardiac troponin assays to improve the sensitivity of detection of cardiac necrosis and to decrease over time the amount of change (or delta) in cardiac troponin concentrations needed to be considered significant (1, 2 ). During the time period when assays were insufficiently precise at very low levels, we and others advocated using as a cutoff ...
متن کاملConcordance, variance, and outliers in 4 contemporary cardiac troponin assays: implications for harmonization.
BACKGROUND Data to standardize and harmonize the differences between cardiac troponin assays are needed to support their universal status in diagnosis of myocardial infarction. We characterized the variation between methods, the comparability of the 99th-percentile cutoff thresholds, and the occurrence of outliers in 4 cardiac troponin assays. METHODS Cardiac troponin was measured in duplicat...
متن کاملDiagnosing acute myocardial infarction with troponins: how low can you go?
BACKGROUND Recent consensus guidelines state that acute myocardial infarction (AMI) may be diagnosed in the context of a troponin rise above the 99th percentile of the upper reference limit (URL) with the optimal imprecision of the assay (coefficient of variation, CV) being <or=10%. However, at the 99th percentile, modern assays do not have a CV <or=10%. Objective The authors compared the progn...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 51 11 شماره
صفحات -
تاریخ انتشار 2005